Take a creative workshop. Lots of places both in the U.S. and abroad offer week- or month-long courses in writing, painting, photography, sculpting, music, acting, archaeology, or whatever you’ve always wanted to try your hand at.
Try a sports camp. There are “camps” galore, including tennis, golf, scuba diving, riding, baseball, and rock climbing.
Vacation at a cooking school. Your eyes, nose, tongue, sense of touch, and emotions will get an extra workout, and you’ll develop mental skills planning, timing, and executing complex tasks.
Novelty is the backbone of any good vacation. Increase the Neurobic potential by adding a learning experience to it.